N-Butyryl-DL-homocysteine thiolactone

N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity[1][2].

Product Specifications

CAS Number

[39837-08-6]

UNSPSC

12352209

Hazard Statement

H315-H319-H335

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/n-butyryl-dl-homocysteine-thiolactone.html

Solubility

10 mM in DMSO

Smiles

O=C(CCC)NC1C(SCC1)=O

Molecular Formula

C8H13NO2S

Molecular Weight

187.26

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Khalilzadeh P, et al. Growth inhibition of adherent Pseudomonas aeruginosa by an N-butanoyl-L-homoserine lactone analog. Can J Microbiol. 2010 Apr;56 (4) :317-25.|[2]Iyer R, et al. Synthetic analogs of bacterial quorum sensors: US, US20110053890[P]. 2011-03-03.