(3S,4S)-Tofacitinib

(3S,4S)-Tofacitinib is the less active S-enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

JAK

Reference compound

Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

COVID-19-immunoregulation

Inflammation/Immunology

https://www.medchemexpress.com/_3S,4S_-Tofacitinib.html

99.75

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

CN(C1=NC=NC2=C1C=CN2)[C@H]3[C@@H](C)CCN(C(CC#N)=O)C3

312.37

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-40354C/3S-4S-Tofacitinib-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-40354C/3S-4S-Tofacitinib-SDS-MedChemExpress.pdf

No Development Reported

1092578-47-6