Manumycin B
Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 15 mM[1][2].
Product Specifications
CAS Number
139023-58-8
UNSPSC
12352005
Target
Antibiotic; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/manumycin-b.html
Smiles
CCCC[C@@H](C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O
Molecular Formula
C28H34N2O7
Molecular Weight
510.58
References & Citations
[1]Zheng ZH, et al., Isolation and characterization of N98-1272 A, B and C, selective acetylcholinesterase inhibitors from metabolites of an actinomycete strain. J Enzyme Inhib Med Chem. 2007 Feb;22 (1) :43-9.|[2]Grové J J C, et al., The first total synthesis of a type II manumycin antibiotic, (+) -TMC-1 A: the total syntheses of (–) -LL-C10037β and (+) -manumycin B[J]. Chemical Communications, 1999 (5) : 421-422.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE
Frequently Asked Questions
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