PROTAC BRM/BRG1 degrader-4
PROTAC BRM/BRG1 degrader-4 (example 047) is a potent BRM and BRG1 PROTAC degrader, with DC50 values of 0.21 nM and 3.4 nM in SW1573 cells, respectively (Pink: ligand for target protein ; Black: linker (HY-28911) ; Blue: E3 ligase ligand (HY-168253) ).
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brm-brg1-degrader-4.html
Smiles
CNC(C1=C2C=C(C3=C(O)C=CC=C3)N=N1)=NN2C4CCN(CCOC5=NOC(C(C(N6C[C@H](O)C[C@H]6C(N[C@@H](C)C7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)C(C)C)=C5)CC4
Molecular Formula
C44H52N10O6S
Molecular Weight
849.01
References & Citations
[1]Peng Gu, et al. Brm selective degradation agent compound and use thereof. WO2023093728A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD81 / TAPA-1 (1.3.3.22), CF770 conjugate, 0.1mg/mL
Cytokeratin 17 (E3), CF568 conjugate, 0.1mg/mL
