MRTX-1257
Product Specifications
Product Name Alternative
Prodigiosine; NSC47147
UNSPSC Description
MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MRTX-1257.html
Purity
99.14
Solubility
DMSO : 55 mg/mL (ultrasonic)
Smiles
N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1
Molecular Weight
565.71
References & Citations
[1]Matthew et al. Structure-Based Drug Discovery of MRTX1257, a Selective, Covalent KRAS G12C Inhibitor with Oral Activity in Animal Models of Cancer.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114436/MRTX-1257-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114436/MRTX-1257-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2206736-04-9
Available Sizes
Curated Selection
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