UNC10142

UNC10142 (Compound 44) is a first-in-class small molecule antagonist of CHD1 that binds with an IC50 value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc10142.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OCCCN2CCCCC2)C=C(N=C(N3CCCCCCCC3)N=C4N(C)C5CCN(C(C)=O)CC5)C4=C1

Molecular Formula

C33H52N6O3

Molecular Weight

580.80

References & Citations

[1]Johnson RL, et al. Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer. J Med Chem. 2024 Nov 28;67 (22) :20056-20075.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

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