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Phospho-PKR (T451) Recombinant Rabbit Monoclonal Antibody [JE46-70]

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene on chromosome 2. PKR is a serine/tyrosine kinase that is 551 amino acids long. PKR is inducible by various mechanisms of stress and protects against viral infections. It also has a role in several signaling pathways.

Product Specifications

Product Name Alternative

Double stranded RNA activated protein kinase; antibody E2AK2_HUMAN antibody eIF-2A protein kinase 2 antibody EIF2AK1 antibody EIF2AK2 antibody Eukaryotic translation initiation factor 2 alpha kinase 2 antibody Eukaryotic translation initiation factor 2-alpha kinase 2 antibody HGNC:9437 antibody Interferon induced double stranded RNA activated protein kinase antibody Interferon inducible elF2 alpha kinase antibody Interferon inducible RNA dependent protein kinase antibody Interferon-induced, double-stranded RNA-activated protein kinase antibody Interferon-inducible RNA-dependent protein kinase antibody MGC126524 antibody P1/eIF-2A protein kinase antibody P1/eIF2A protein kinase antibody p68 kinase antibody PKR antibody PPP1R83 antibody PRKR antibody Protein kinase interferon inducible double stranded RNA dependent antibody Protein kinase RNA activated antibody Protein kinase RNA-activated antibody Protein phosphatase 1 regulatory subunit 83 antibody Serine/threonine protein kinase TIK antibody Tyrosine protein kinase EIF2AK2 antibody

Abbreviation

EIF2AK2, PKR, PRKR

Swiss Prot

P19525 Human

Cellular Locus

Cytoplasm, Nucleus, perinuclear region.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues surrounding Thr45 of human PKR protein.

Isotype

IgG

Clone

JE46-70

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC, IF-Cell

Positive Control

HeLa treated with 10ng/mL IFN-α1 for 18 hours then 100nM Calyculin A for 15 minutes cell lysate, HeLa cells treated with 10ng/mL IFN-α1 for 18 hours then add 100nM Calyculin A for 15 minutes.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;FC: 1:1,000 ;IF-Cell: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 62 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes

CAS Number

9000-83-3

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