EGFR/VEGFR2-IN-1
EGFR/VEGFR2-IN-1 (Compound 10e) is a VEGFR-2 and EGFR inhibitor (IC50: 0.26 and 0.14 μM respectively) . EGFR/VEGFR2-IN-1 inhibits tubulin polymerization with an IC50 of 40.9 μM. EGFR/VEGFR2-IN-1 induces apoptosis. EGFR/VEGFR2-IN-1 can be used for research of antileukemia and antilymphoma[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR; Microtubule/Tubulin; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-vegfr2-in-1.html
Smiles
O=C(CNC(S/C1=C\C2=CC=CC=C2O)=NC1=O)N(C3=C4CCCC3)C5=C4C=C(Cl)C=C5
Molecular Formula
C24H20ClN3O3S
Molecular Weight
465.95
References & Citations
[1]Ali BS, et al. Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biological and molecular docking studies. Bioorg Chem. 2024 Sep 10;153:107817.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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