JAK3-IN-14
JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].
Product Specifications
CAS Number
[454234-24-3]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak3-in-14.html
Purity
99.32
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=C(C3=CN=CC=C3)C=C2/C1=C/C4=CC=CN4
Molecular Formula
C18H13N3O
Molecular Weight
287.32
References & Citations
[1]Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16 (21) :5633-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; JAK3
Available Sizes
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