HDAC-IN-77
HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; HDAC; Keap1-Nrf2
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-77.html
Smiles
O=C(/C=C/C1=CC=C(CSC2=NC3=CC=CC=C3N2CCCN(C)C)C=C1)NO
Molecular Formula
C22H26N4O2S
Molecular Weight
410.53
References & Citations
[1]Liu M, et al. Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. J Med Chem. 2024 Sep 12;67 (17) :15098-15117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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