HDAC-IN-77

HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; HDAC; Keap1-Nrf2

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; NF-κB

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-77.html

Smiles

O=C(/C=C/C1=CC=C(CSC2=NC3=CC=CC=C3N2CCCN(C)C)C=C1)NO

Molecular Formula

C22H26N4O2S

Molecular Weight

410.53

References & Citations

[1]Liu M, et al. Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. J Med Chem. 2024 Sep 12;67 (17) :15098-15117.