MPGES-1/5-LOX-IN-1
MPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact[1].
Product Specifications
UNSPSC
12352005
Target
Lipoxygenase; PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mpges-1-5-lox-in-1.html
Smiles
O=C(C1=C(C)NC(NC1C2=CC=C(OC)C(OC)=C2)=O)NC3=CC=C(S(=O)(N)=O)C=C3
Molecular Formula
C20H22N4O6S
Molecular Weight
446.48
References & Citations
[1]Al-Wahaibi LH, et al. Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition. Front Chem. 2024 May 10;12:1387923.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX
Frequently Asked Questions
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