Spongionellol A analog 1
Spongionellol A analog 1, an analog of Spongionellol A , is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase?dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spongionellol-a-analog-1.html
Solubility
10 mM in DMSO
Smiles
CC(O[C@H]1[C@]23[C@]([C@@H](CC[C@]2([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC3)C)C(OC)=O)([H])[C@@H](O1)OC(C)=O)=O
Molecular Formula
C25H38O7
Molecular Weight
450.57
References & Citations
[1]Sergey A Dyshlovoy, et al. New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein. Sci Rep. 2022 Aug 9;12 (1) :13570.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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