SCH 486757

SCH 486757 is an orally effective pain peptide receptor (NOP) agonist. SCH 486757 can be used for the study of cough[1].

Product Specifications

CAS Number

[524019-25-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sch-486757.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(C=CC=C1)C(C(C=CC=C2)=C2Cl)N([C@H]3C4)[C@@H](CC3)C[C@@]4(C5=NC=CC=N5)O

Molecular Formula

C24H23Cl2N3O

Molecular Weight

440.36

Precautions

P261-P280-P302+P352

References & Citations

[1]McLeod RL, et al. Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis (2-Chlorophenyl) Methyl]-3- (2-Pyrimidinyl) -8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models. Eur J Pharmacol. 2010 Mar 25;630 (1-3) :112-20.