DEC-RVRK-CMK
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM) . The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position[1].
Product Specifications
CAS Number
534615-50-4
Product Name Alternative
Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
UNSPSC
12352209
Target
Furin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dec-rvrk-cmk.html
Solubility
10 mM in DMSO
Smiles
NCCCC[C@@H](C(CCl)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCC)=O)=O)=O)=O
Molecular Formula
C34H66ClN11O5
Molecular Weight
744.41
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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