Lumasiran
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) [1][2].
Product Specifications
CAS Number
1834610-13-7
Product Name Alternative
ALN-G01
UNSPSC
12352208
Target
Glycolate Oxidase; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lumasiran.html
Purity
98.77
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Lumasiran]
Molecular Formula
C530H712F10N173O320P43S6
Molecular Weight
16339.00
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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