RET/TRKA-IN-1
RET/TRKA-IN-1 (Compound 13) is a dual inhibitor for RET (IC50=0.375 µM) and TRKA. RET/TRKA-IN-1 inhibits cell viability of LC-2 and KM12, with GI50 of 0.72 and 0.25 μM. RET/TRKA-IN-1 arrests the cell cycle at G1 phase[1].
Product Specifications
CAS Number
[3048634-52-9]
UNSPSC
12352005
Target
RET; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-trka-in-1.html
Smiles
CN1N=CC(C2=CC=C(C3=C(NC4=CC=C(CC(NC5=CC(C(C)(C)C)=NN5C)=O)C=C4)N=CN=C3N6)C6=C2)=C1
Molecular Formula
C30H31N9O
Molecular Weight
533.63
References & Citations
[1]Acharya B, et al., Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors. Bioorg Med Chem. 2024 May 15;106:117749.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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