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Y06137

Y06137 is a potent and selective BET inhibitor for treatment of castration-resistant prostate cancer (CRPC) . Y06137 binds to the BRD4 (1) bromodomain with a Kd of 81 nM[1].

Product Specifications

CAS Number

2226534-49-0

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Y06137.html

Purity

99.90

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC1=NOC(C1=C2)=CC=C2C3=NC(C=C4)=C(N3CC5CCCCC5)C=C4N6CCOC[C@@H]6C

Molecular Formula

C27H32N4O2

Molecular Weight

444.57

References & Citations

[1]Zhang M, et al. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) . J Med Chem. 2018 Apr 12;61 (7) :3037-3058.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BRD4

Available Sizes

Frequently Asked Questions

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