INCB059872 (dihydrochloride)
INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia[1].
Product Specifications
CAS Number
[3062683-32-0]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/incb059872-dihydrochloride.html
Purity
99.64
Solubility
DMSO : 3.57 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC(C1(CCC1)CN2CCC(COC)(CC2)CN[C@H]3[C@@](C4=CC=CC=C4)([H])C3)=O.[H]Cl.[H]Cl
Molecular Formula
C23H36Cl2N2O3
Molecular Weight
459.45
References & Citations
[1]Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
KDM1/LSD1
Available Sizes
Curated Selection
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