Pumafentrine
Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C) -induced colitis in a preventive setting[1].
Product Specifications
CAS Number
207993-12-2
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pumafentrine.html
Smiles
COC1=C(OCC)C=C([C@@]2([H])[C@@](CCN(C2)C)([H])N=C3C4=CC=C(C=C4)C(N(C(C)C)C(C)C)=O)C3=C1
Molecular Formula
C29H39N3O3
Molecular Weight
477.64
References & Citations
[1]Florian Rieder, et al. The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. PLoS One. 2013;8 (2) :e56867.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE3; PDE4
Available Sizes
Frequently Asked Questions
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