Anti-Thyroglobulin Antibody

Mouse Monoclonal Antibody specific to Thyroglobulin

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Gene Name

NCBI Gene ID

UniProt

P01266

Cellular Locus

Secreted

Host

Mouse

Reactivity

Human

Immunogen

Purified human thyroglobulin

Target Antigen

Thyroglobulin

Target

Thyroglobulin

Clonality

Monoclonal

Isotype

IgM

Type

Antibody

Applications

ELISA

Field of Research

Hormones/Proteins

Purification Method

Purified by protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). {PubMed:17532758, PubMed:32025030}.