MRT-92
MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM) . MRT-92 can be used in the study of cerebellar glioma[1].
Product Specifications
CAS Number
1428315-82-5
UNSPSC
12352005
Target
Hedgehog; Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrt-92.html
Smiles
O=C(NC(NC1=CC=C(C)C(NC(C2=CC=C(CCC3=CC=CC=C3)C=C2)=O)=C1)=N)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C33H34N4O5
Molecular Weight
566.65
References & Citations
[1]Hoch, et al. "MRT-92 inhibits Hedgehog signaling by blocking overlap** binding sites in the transmembrane domain of the Smoothened receptor." The FASEB Journal 29.5 (2015) : 1817.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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