Hypericin-d10

Hypericin-d10 is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Apoptosis; Influenza Virus; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Others

Field of Research

Cancer

Purity

95.32

Solubility

DMSO : 250 mg/mL (ultrasonic; warming)

Smiles

O=C1C2=C(O)C([2H])=C(O)C3=C2C4=C(C5=C6C(O)=C([2H])C(C([2H])([2H])[2H])=C5C7=C4C1=C(O)C([2H])=C7C([2H])([2H])[2H])C8=C3C(O)=C([2H])C(O)=C8C6=O

Molecular Formula

C30H6D10O8

Molecular Weight

514.50

Precautions

H302, H317

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34 (3) :221-41.|[3]Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90 (1) :158-62.|[4]Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21 (4A) :2649-55.