Hypericin-d10
Hypericin-d10 is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H317
Target
Apoptosis; Influenza Virus; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Field of Research
Cancer
Purity
95.32
Solubility
DMSO : 250 mg/mL (ultrasonic; warming)
Smiles
O=C1C2=C(O)C([2H])=C(O)C3=C2C4=C(C5=C6C(O)=C([2H])C(C([2H])([2H])[2H])=C5C7=C4C1=C(O)C([2H])=C7C([2H])([2H])[2H])C8=C3C(O)=C([2H])C(O)=C8C6=O
Molecular Formula
C30H6D10O8
Molecular Weight
514.50
Precautions
H302, H317
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Agostinis P et al. Hypericin in cancer treatment: more light on the way.
 Int J Biochem Cell Biol. 2002 Mar;34 (3) :221-41.|[3]Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90 (1) :158-62.|[4]Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin.
 Anticancer Res. 2001 Jul-Aug;21 (4A) :2649-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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