N-Acetyl dapsone

N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688) . Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

Product Specifications

CAS Number

[565-20-8]

Product Name Alternative

MADDS; Monoacetyldapsone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-acetyl-dapsone.html

Solubility

10 mM in DMSO

Smiles

CC(NC1=CC=C(S(=O)(C2=CC=C(N)C=C2)=O)C=C1)=O

Molecular Formula

C14H14N2O3S

Molecular Weight

290.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Tanaka K, et al. Mutagenicity of N-acetyl and N, N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143 (1-2) :11-5.|[2]Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.