ZJCK-6-46
ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+) . ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo[1].
Product Specifications
UNSPSC
12352005
Target
DYRK; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zjck-6-46.html
Smiles
CC1=NC2=C(C=C1)C(C3=CC4=C(C=C3)N=CN=C4N[C@@H](C5=CC=CC=C5)CO)=CN2
Molecular Formula
C24H21N5O
Molecular Weight
395.46
References & Citations
[1]Huanhua Chen, et al. Discovery of ZJCK-6-46: A Potent, Selective, and Orally Available Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor for the Treatment of Alzheimer's Disease. J Med Chem. 2024 Aug 8;67 (15) :12571-12600.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1; DYRK2; DYRK3; DYRK4
Available Sizes
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