ZJCK-6-46

ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+) . ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo[1].

Product Specifications

UNSPSC

12352005

Target

DYRK; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zjck-6-46.html

Smiles

CC1=NC2=C(C=C1)C(C3=CC4=C(C=C3)N=CN=C4N[C@@H](C5=CC=CC=C5)CO)=CN2

Molecular Formula

C24H21N5O

Molecular Weight

395.46

References & Citations

[1]Huanhua Chen, et al. Discovery of ZJCK-6-46: A Potent, Selective, and Orally Available Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor for the Treatment of Alzheimer's Disease. J Med Chem. 2024 Aug 8;67 (15) :12571-12600.