PfSUB1-IN-1
PfSUB1-IN-1 (compound 4c) is a plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1) Inhibitor (IC50: 15 nM) . PfSUB1 is an antimalarial target. PfSUB1-IN-1 inhibits the growth of a genetically modified P. falciparum line expressing reduced levels of PfSUB1 13-fold more efficiently compared to a wild-type parasite line[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfsub1-in-1.html
Smiles
O=C(N[C@@H](C1CCCC1)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC2)B(O)OC2=O)=O)=O)=O)C3=CC(C)=CC(C)=C3
Molecular Formula
C28H41BN4O7
Molecular Weight
556.46
References & Citations
[1]Withers-Martinez C, et al. Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. J Med Chem. 2024 Aug 8;67 (15) :13033-13055.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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