UNC9994 (hydrochloride)

UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity[1].

Product Specifications

CAS Number

[2108826-33-9]

UNSPSC

12352005

Target

5-HT Receptor; Arrestin; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/unc9994-hydrochloride.html

Concentration

10mM

Purity

99.50

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

ClC1=C(Cl)C(C2CCN(CCCOC3=CC=C(SC=N4)C4=C3)CC2)=CC=C1.Cl

Molecular Formula

C21H23Cl3N2OS

Molecular Weight

457.84

References & Citations

[1]Allen JA, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011 Nov 8;108 (45) :18488-93.