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TLR8 agonist 9

TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 [1].

Product Specifications

CAS Number

3034750-61-0

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tlr8-agonist-9.html

Smiles

O=C(C=CC1=O)N1CC2OCC(C(N3CCC4=NC=C(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)C=C4C3)=O)CO2

Molecular Formula

C38H43N7O8

Molecular Weight

725.79

References & Citations

[1]Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR8

Frequently Asked Questions

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