2-Hydroxy Ibuprofen-d6

2-Hydroxy Ibuprofen-d6 is the deuterium labeled 2-Hydroxy Ibuprofen. 2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

Product Specifications

CAS Number

[1217055-71-4]

Product Name Alternative

(±) -2-Hydroxy Ibuprofen-d6

UNSPSC

12352005

Target

COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Field of Research

Cancer; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])C(C([2H])([2H])[2H])(O)CC1=CC=C(C=C1)C(C)C(O)=O

Molecular Formula

C13H12D6O3

Molecular Weight

228.32

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61 (1) :2-7.