AR-C155858

AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively.

Product Specifications

CAS Number

[496791-37-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Monocarboxylate Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ar-c155858.html

Purity

99.62

Solubility

DMSO : 70 mg/mL (ultrasonic)

Smiles

O=C(C1=C2SC(CC3=C(NN=C3C)C)=C1C(N4C[C@@H](CO4)O)=O)N(C(N2CC(C)C)=O)C

Molecular Formula

C21H27N5O5S

Molecular Weight

461.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Ovens MJ, et al. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem J. 2010 Oct 15;431 (2) :217-25.|[2]Ovens MJ, et al. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425 (3) :523-30.|[3]Vijay N, et al. A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose. Pharm Res. 2015 Jun;32 (6) :1894-906.