ERK-MYD88 interaction inhibitor 1
ERK-MYD88 interaction inhibitor 1 is an ERK-MYD88 interaction inhibitor. ERK-MYD88 interaction inhibitor 1 can induce an HRI-mediated integrated stress response (ISR), leading to cancer cell-specific immunogenic cell apoptosis (apoptosis) . ERK-MYD88 interaction inhibitor 1 can induce anti-tumor T cell responses in Lewis lung cancer mice, exhibiting anti-tumor activity[1].
Product Specifications
CAS Number
2215927-89-0
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erk-myd88-interaction-inhibitor-1.html
Purity
99.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CN(C)C(C=C1)=CC=C1C2=NC3=CC(C(NC4=CN=C(OC)C=C4)=O)=CC=C3N2
Molecular Formula
C22H21N5O2
Molecular Weight
387.43
References & Citations
[1]Virard F, et al. Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death. Nat Commun. 2024 Aug 15;15 (1) :7037.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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