PARP1-IN-11

PARP1-IN-11 (compound 49) is a potent PARP1 inhibitor with IC50 value of 0.082 µM. PARP1-IN-11 shows complete inhibition of PARP2 and substantially inhibits PARP3, TNKS1 and TNKS2[1].

Product Specifications

CAS Number

[2482484-87-5]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp1-in-11.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C(NC/2=O)=CC=C1)OC2=C/C3=CC=C(O)C=C3)N

Molecular Formula

C16H12N2O4

Molecular Weight

296.28

References & Citations

[1]Shao X, et al. Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors. Bioorg Chem. 2020 Sep;102:104075.