Cholesta-3,5-diene

Cholesta-3,5-diene is an inflammatory modulator that targets immune cells such as neutrophils and accelerates wound healing by promoting neutrophil chemotaxis and fibroblast migration. Cholesta-3,5-diene enhances immune cell recruitment and extracellular matrix deposition by activating chemokine receptor-mediated signaling pathways such as PI3K/Akt. Cholesta-3,5-diene can be applied topically to wound repair and has potential therapeutic value in chronic ulcers or skin lesions[1][2].

Product Specifications

CAS Number

[747-90-0]

Product Name Alternative

Delta-3,5-Cholestadiene

UNSPSC

12352200

Hazard Statement

H302

Target

Akt; PI3K

Type

Biochemical Assay Reagents

Related Pathways

PI3K/Akt/mTOR

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cholesta-3-5-diene.html

Purity

99.54

Solubility

Ethanol : 2 mg/mL (ultrasonic)

Smiles

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C=CCC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C27H44

Molecular Weight

368.64

Precautions

H302

References & Citations

[1]Al-Hassan JM, et al. Potential Mechanism of Dermal Wound Treatment With Preparations From the Skin Gel of Arabian Gulf Catfish: A Unique Furan Fatty Acid (F6) and Cholesta-3,5-Diene (S5) Recruit Neutrophils and Fibroblasts to Promote Wound Healing. Front Pharmacol. 2020 Jun 18;11:899.|[2]Derewiaka D. Formation of cholesterol oxidation products, cholesterol dimers and cholestadienes after thermal processing of cholesterol standards and butter[J]. European Journal of Lipid Science and Technology, 2019, 121 (9) : 1800373.