Sanazole

Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis. These characteristics make Sanazole a promising candidate for research in tumor therapy[1][2].

Product Specifications

CAS Number

[104958-90-9]

Product Name Alternative

AK-2123

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sanazole.html

Smiles

O=C(NCCOC)CN1N=C([N+]([O-])=O)N=C1

Molecular Formula

C7H11N5O4

Molecular Weight

229.19

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Rajagopalan, et al. Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma. Journal of radiation research 44.4 (2003) : 359-365.|[2]García-Angulo, et al. "Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II–III—preliminary positive results." International Journal of Radiation Oncology Biology Physics 22.3 (1992) : 589-591.