PD-L1-IN-7
PD-L1-IN-7 (compound CB31) is an inhibitor of PD-L1, which can induce PD-L1 internalization and PD-L1 retention in cells. PD-L1-IN-7 can inhibit the interaction of PD-1/PD-L1 (IC50: 0.2 nM), change the glycosylation pattern, and promote PD-L1 degradation. PD-L1-IN-7 can also enhance T cell infiltration, amplify T cell function and the ability to kill tumor cells[1].
Product Specifications
CAS Number
3024733-03-4
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-l1-in-7.html
Smiles
CC1=C(C=CC=C1C2=NC3=CC(CN([C@@H]4CC[C@H](CC4)C(O)=O)C)=CC(C#N)=C3O2)C5=C6C(N(C7=CC(OC)=C(C(OC)=C7)CN([C@H]8[C@H](COCC8)O)C)N=C6)=CC=C5
Molecular Formula
C46H50N6O7
Molecular Weight
798.93
References & Citations
[1]Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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