Bisindolylmaleimide III

Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC) . Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein kinase 1 after activation of these kinases[1].

Product Specifications

CAS Number

[137592-43-9]

Product Name Alternative

(±)-Pirmenol (hydrochloride); CI-845,Vatensol

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bisindolylmaleimide-iii.html

Purity

98.95

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O

Molecular Formula

C23H20N4O2

Molecular Weight

384.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Brehmer D, et, al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3 (5) :490-500. |[2]Saito Y, et, al. Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. Mol Cell Endocrinol. 1999 Jun 25;152 (1-2) :65-72.