Bisindolylmaleimide III
Product Specifications
Product Name Alternative
(±)-Pirmenol (hydrochloride); CI-845,Vatensol
UNSPSC Description
Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein kinase 1 after activation of these kinases[1].
Target Antigen
PKC
Type
Reference compound
Related Pathways
Epigenetics;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bisindolylmaleimide-iii.html
Purity
98.95
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O
Molecular Weight
384.43
References & Citations
[1]Brehmer D, et, al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500. |[2]Saito Y, et, al. Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. Mol Cell Endocrinol. 1999 Jun 25;152(1-2):65-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117393/Bisindolylmaleimide-III-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117393/Bisindolylmaleimide-III-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
137592-43-9
Available Sizes
Curated Selection
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