SJ-C1044
Product Specifications
UNSPSC Description
SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values ??of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2, TIE2, and CSF1R, with IC50 values ??of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer[1].
Target Antigen
c-Fms; ERK; MEK; Raf; Ras; Tie; VEGFR
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj-c1044.html
Smiles
FC(C(NC(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)=C2)=CC=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5
Molecular Weight
561.41
References & Citations
[1]Sungpyo Hong, et al. "Targeting RAF isoforms and tumor microenvironments in RAS or BRAF mutant colorectal cancers with SJ-C1044 for anti-tumor activity." Current Issues in Molecular Biology 45.7 (2023): 5865-5878.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164529/SJ-C1044-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164529/
Clinical Information
No Development Reported
CAS Number
2121503-76-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6229607-01 0.1 mL
RCN1 (reticulocalbin 1, EF-hand Calcium Binding Domain, FLJ37041, PIG20, RCAL, RCN) (MaxLight 650)
Ask
View Details MBS6229607-02 5x 0.1 mL
RCN1 (reticulocalbin 1, EF-hand Calcium Binding Domain, FLJ37041, PIG20, RCAL, RCN) (MaxLight 650)
Ask
View Details