Tedisamil
Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I (to) ) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K (ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models[1].
Product Specifications
CAS Number
[90961-53-8]
Product Name Alternative
KC-8857
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tedisamil.html
Smiles
[C@@H](CN1CC2CC2)(C3)C4(CCCC4)[C@@H](C1)CN3CC5CC5
Molecular Formula
C19H32N2
Molecular Weight
288.47
References & Citations
[1]Doggrell SA. Tedisamil: master switch of nature? Expert Opin Investig Drugs. 2001 Jan;10 (1) :129-38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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