TB-11
TB-11 is a Cathepsin D inhibitor, with IC50s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research[1].
Product Specifications
CAS Number
[1415033-93-0]
UNSPSC
12352005
Target
Beta-secretase; Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tb-11.html
Smiles
CC(C)(C)OC(N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(OC)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C52H78N8O12
Molecular Weight
1007.22
References & Citations
[1]Li Z, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25 (4) :e3154.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
BACE1; Cathepsin D; Cathepsin E
Curated Selection
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