PF-05212377

PF-05212377 (SAM-760) is an inhibitor for serotonin receptor 5-HT6. PF-05212377 is a substrate for P-gp/non-BCRP human transporter. PF-05212377 exhibits blood brain barrier permeability in non-human primates. PF-05212377 can be used for Alzheimer’s Disease research[1][2].

Product Specifications

CAS Number

[1226793-34-5]

Product Name Alternative

SAM-760

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pf-05212377.html

Smiles

O=S(N1C2=CC=CC(N3CCNCC3)=C2N=C1C)(C4=CC=CC=C4)=O

Molecular Formula

C18H20N4O2S

Molecular Weight

356.44

References & Citations

[1]Fullerton T, et al., A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer's disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil. Alzheimers Res Ther. 2018 Apr 5;10 (1) :38.|[2]Sawant-Basak A, et al., Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT6 receptor occupancy from non-human primates to humans. Biopharm Drug Dispos. 2023 Feb;44 (1) :48-59.