UBE2T/FANCL-IN-1
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].
Product Specifications
CAS Number
[1359415-02-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ube2t-fancl-in-1.html
Purity
99.83
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(CCCC1)N1CC2=NN3C(N4CCN(CC)CC4)=CC(C)=NC3=N2
Molecular Formula
C19H31N7
Molecular Weight
357.50
Precautions
H302, H315, H318, H335
References & Citations
[1]Cornwell MJ, et al. Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway. ACS Chem Biol. 2019;14 (10) :2148-2154.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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