UBE2T/FANCL-IN-1

UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1].

Product Specifications

CAS Number

[1359415-02-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ube2t-fancl-in-1.html

Purity

99.83

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(CCCC1)N1CC2=NN3C(N4CCN(CC)CC4)=CC(C)=NC3=N2

Molecular Formula

C19H31N7

Molecular Weight

357.50

Precautions

H302, H315, H318, H335

References & Citations

[1]Cornwell MJ, et al. Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway. ACS Chem Biol. 2019;14 (10) :2148-2154.