28-Deoxonimbolide
28-Deoxonimbolide is a Nimbin type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways[1].
Product Specifications
CAS Number
126005-94-5
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/28-deoxonimbolide.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)C[C@@H]([C@]1(C)C2=C(C)[C@H](C3=COC=C3)C[C@@]2([H])O[C@]1([H])[C@@](OC4)([H])[C@@]5([H])[C@@]4(C)C=C6)[C@@]5(C)C6=O
Molecular Formula
C27H32O6
Molecular Weight
452.54
References & Citations
[1]Kikuchi T, et al. Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem) . J Nat Prod. 2011 Apr 25;74 (4) :866-70.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8; Caspase 9
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