ProTx-III
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK) . ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia[1].
Product Specifications
CAS Number
1808297-63-3
Product Name Alternative
μ-TRTX-Tp1a
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/protx-iii.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@H](CC)C)=O)CC4=CNC=N4)=O)CC(C)C)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC5=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CC(N)=O)=O)CC8=CNC=N8)=O)CC(N)=O)=O)CO)=O)=O)=O)CCCCN)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC%11=CC=CC=C%11)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5CCCCN)=O)CC(C)C)=O)=O)CO)=O
Molecular Formula
C162H246N52O43S6
Molecular Weight
3802.40
References & Citations
[1]Cardoso FC, et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol Pharmacol. 2015 Aug;88 (2) :291-303.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Nav1.7
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