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Anti-Hsp90 Antibody

Rabbit Polyclonal Antibody specific to Hsp90

Product Specifications

Product Name Alternative

HSP 90, Heat shock 84 kDa, HSP 84, HSP84

Gene Name

HSP90AB1

Gene ID

3326

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=HSP90AB1">HSP90AB1</a>

UniProt

P08238

Accession Number

NP_031381.2

Cellular Locus

Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane, Dynein axonemal particle

Host

Rabbit

Reactivity

Eukaryote

Immunogen

Full-length Hsp90 protein.

Target Antigen

Heat shock protein HSP 90-beta

Target

Hsp90

Clonality

Polyclonal

Type

Antibody

Applications

WB, IHC, ICC/IF, IP, ELISA

Field of Research

Heat Shock& Stress Proteins

Purification Method

Whole antiserum

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Whole Antiserum

Form

Liquid

Buffer

Whole Antiserum

Function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate rPubMed:16478993, PubMed:18239673, PubMed:19696785, PubMed:20353823, PubMed:24613385, PubMed:32272059, PubMed:25973397, PubMed:26991466, PubMed:27295069}.

Additionnal Information

Immunoblotting: use at 1:20,000- 1:40,000 (ECL). A band of ~90 kDa is detected.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/11107.pdf

Specificity

This antibody recognizes eukaryotic Hsp90alphab.

Formulation

Whole antiserum

Target Background

Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Hsp90 is involved in the folding, assembly, maturation, and stabilization of specific proteins as a member of a chaperone complex. It is also highly expressed in unstressed cells where it participates in controlling the activity, turnover, and trafficking of a variety of proteins. Most of the Hsp90-regulated proteins are involved in cell signaling and include the kinases, v-Src, Wee1, c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of hepatitis B virus and telomerase.

CAS Number

9007-83-4

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