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Tryptanthrin (Standard)

Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2].

Product Specifications

CAS Number

13220-57-0

UNSPSC

12352005

Target

COX; Interleukin Related; Leukotriene Receptor; NF-κB; NO Synthase; Reference Standards; TNF Receptor

Type

Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tryptanthrin-standard.html

Purity

98.77

Smiles

O=C1C2=CC=CC=C2N3C(C4=CC=CC=C4N=C13)=O

Molecular Formula

C15H8N2O2

Molecular Weight

248.24

References & Citations

[1]Zeng Q, et, al. Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment. Acta Pharm. 2021 Jun 1;71 (2) :245-266.|[2]Pergola C, et, al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo. Br J Pharmacol. 2012 Feb;165 (3) :765-76.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

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