DHODH-IN-25

DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 nM for human DHODH. DHODH-IN-25 can be used for the study of acute myeloid leukemia (AML) [1].

Product Specifications

CAS Number

[2619531-95-0]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dhodh-in-25.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C(CO)CCC1=O)NC2=CC(O[C@@H](C)C(F)(F)F)=C(C(NC3=C(F)C=CC=C3Cl)=O)C=C2F

Molecular Formula

C22H19ClF5N3O5

Molecular Weight

535.85

References & Citations

[1]DeRatt, Lindsey G., et al. "Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors." ACS Medicinal Chemistry Letters (2024) .