DHODH-IN-25
Product Specifications
UNSPSC Description
DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 nM for human DHODH. DHODH-IN-25 can be used for the study of acute myeloid leukemia (AML)[1].
Target Antigen
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-25.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C(CO)CCC1=O)NC2=CC(O[C@@H](C)C(F)(F)F)=C(C(NC3=C(F)C=CC=C3Cl)=O)C=C2F
Molecular Weight
535.85
References & Citations
[1]DeRatt, Lindsey G., et al. "Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors." ACS Medicinal Chemistry Letters (2024).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163328/DHODH-IN-25-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163328/
Clinical Information
No Development Reported
CAS Number
2619531-95-0
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