Cyclosporin H

Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1) . Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs) . Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952) . Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

Product Specifications

CAS Number

[83602-39-5]

UNSPSC

12352209

Hazard Statement

H302, H350, H360

Target

Formyl Peptide Receptor (FPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cyclosporin-h.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@@](N(C([C@@H](N(C([C@](N(C([C@H](NC([C@@H](NC([C@H](CC(C)C)N(C)C([C@@](C(C)C)([H])NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](CC)NC1=O)=O)=O)=O)=O)=O)C)=O)C)=O)C)([H])CC(C)C)=O)C)CC(C)C)=O)C)([H])C(C)C)=O)C)O

Molecular Formula

C62H111N11O12

Molecular Weight

1202.61

Precautions

H302, H350, H360

References & Citations

[1]Zhang X, et al. Mitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT: a potential mechanism involved in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018;315 (5) :L775-L786.|[2]Wenzel-Seifert K, et al. Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. J Immunol. 1993;150 (10) :4591-4599.