HPK1-IN-8
HPK1-IN-8 is an allosteric, inactive conformation-selective inhibitor of full-length HPK1.
Product Specifications
CAS Number
[1214561-09-7]
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-8.html
Purity
98.56
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC=C(CC2=CC=CC=C2F)S1)CC3=C(C)N=C(NN=C4C)N4C3=O
Molecular Formula
C19H17FN6O2S
Molecular Weight
412.44
References & Citations
[1]Wang W, et al. Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay. Biochemistry. 2021 Oct 19;60 (41) :3114-3124.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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